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ªº¬ðÅÜÅé(5/9¡A55.6%)¡A¦Óµá«ß»«¤H¤]¤£¤Ö¦³³o¬ðÅÜÅé(7/53,13.2%)¡C
¦P¼Ë¦a¡A¥xÆW¤H1%¥H¤Uªº1360C¡÷T¦bµá«ß»«¤H¤¤¬O³Ì¦hªº¡A¦û¦³66%(
35/53)¡A¼d°ê¤H11%(1/9)¤]¦³¡A¬Æ¦Ü©óMelanesiaªºVanuatu¦C®q¤]¦³¦¹
1360C¡÷Tªº³ø¾É(18)¡C487G¡÷A¦b¥xÆW¥u¦³1.2%¡A¦ý¬O·s¥[©Yªº°¨¨Ó¦è
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¡B¼s ¦è¤]¦³¡A ¼s ¦è ¹F7.1%¡C(10)
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¦h¤Ö¡C¶¶«K¤@´£¦a¤¤®ü«¬563C¡÷T¤£½×¬O»P1311C¡÷T¦P®É¬ðÅܧ_(§Y©Ò
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¦a¤¤®üªu©¤¡B¤¤¨È¡B¦L«×¡B¤Ú°ò´µ©Z«Ü´¶¹M¡A¤ö«z¤H¤]¦³(19)¡CµØ¤H
°£¤Wz·s¥[©Y¥~¤@¯ë³£¨S¦³¡C
(7)Áú°ê¡B¤é¥»ªºG6PD¯Ê¥F¯g«Ü¤Ö¡A¤¤°ê¥_¤è¥çµM¡A¥u0.5%¥H
¤U(20)¡A¡C¤é¥»¥Íª«¬ì§Þµo¹F¡A¤@µo²{¦³¯Ê¥F©Î¬ðÅéÅÜ´N¦³¤À¤l¥Íª«
¾Çªº±´´ú¡A¤wª¾¦³¤Q´XºØ¬ðÅÜÅé¡A ¨ä¤¤¤@¬ðÅÜÅéGd-Kimiube(1387CT)
¤] ¦b¥xÆW µo²{¦ýºÙ¬°Gd-Keelung (21)¡C
---------------------------------------------------------------------------
ªí ¤@ ¡R¦U ±Ú ¸s ¨k ©Ê G6PD ¯Ê ¥F ¯g ²± ¦æ ²v
-------------------------------------------------------------------------------
ì ¦í ¥Á ±Ú ¸s ¡R Blackwell(1) Tang(2) º~ ¤H¡R »y ±Ú ©Î Äy ³e (3)
-------------------------------------------------------------------------------
Ami 28/797(3.5%) 6/99(6.1%) «È®a** 16/156(10.3%)
Atayal 0/100 »Ô «n /ºÖ ¦Ñ** 24/963(2.5%)
Bunun 0/341 µØ «n*** 6/150(4.0%)
Paiwan 0/287 ¨ä ¥L 1/370(0.3%)
Puyuma 2/187(1.1%)
Rukai 0/64
Saisiat 3/80(3.8%)* 6/67(9.0%)
Tsou 1/147(0.68%)
Yami 0/54
-------------------------------------------------------------------------------
*Moderate deficient group
**«ö ¥À ¿Ë Á¿ ªº ¥À »y ¡A ¤£ ½× ¬Ù Äy
*** ¥À ¿Ë ¨Ó¦Û ºÖ «Ø ¡B¼s ªF ¡B¶³ «n ¡B¼s ¦è ¡B¶Q ¦{ ¦ý «D ¤W ¨â »y ±Ú
ªí ¤G ¡R ¥x ÆW G6PD ªº ¬ð ÅÜ Åé
----------------------------------------------------------------------------------------------------------------
Chang(4) Lo(5) Huang(6) Tang(7) ChenB(8) ChenH(9)
Hakka/Total M/F Han S-s* Ami Newer**
Sample Size 94 38/247 112/50 197 6 6 97 9
----------------------------------------------------------------------------------------------------------------
1376 G->T Taiwan-Hakka, Canton,Gife 50% 44.7/53% 50/44% 52.3% 1/6 42.3%
1388 G->A Taipei-Hakka, Kaiping, Anant, 21.3% 8.4/10.5% 16.1/18% 16.2% 34.0%
Dhon, Petrich ,Sapporo
493 A->G Taipei 7.4% 5.3/6.9% 8.0/12% 10.2% 4/6 1/6 3.1%
95 A->G Gaohe,Gaozhou 7.4% 0/4.1% 5.4/6% 6.6% 5.2%
1024 C->T Chinese-5 4.3% 0/2.4% 6.2/6% 3.6%
392 G->T Quing-Yan,Chinese-4 1.1% 0/1.2% 1.8/0% 1.0% 4.1%
487 G->A Mahidol 1.1% 2.6/ 0.8% 1.8/0% 1.5%
871 G->A Viangchan 0.9/0% 3***
1360 C->T Union, Maewo,Chinese-2 2.6/0.8% 0.9/0% 1.5%
592 C->T Coimbra, Shunde 2.6/0.8% 4/6
519 C->G Miaoli 2.1% 5
371 A->G 2.1%
Unknown 7.4% 23.6/19.5% 9/14% 7.1% 1/6 1/6 7.2%
517 T->C Nankang 2
835 A->T Chinese-1 1
1387 C->T Keelung, Kimiube 1
1311 C->T 6/48
---------------------------------------------------------------------------------------------------------------
*S-s: Siasiat
** Newer mutants , not in most of earlier reports
***Additional cases discussed but not included in 197 cases
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¾Fªñ½Ñ°ê¡A¦bHawaiiªºµá«ß»«¤H¤¤¦³7.5%(4/50)ªºG6PD¬ðÅÜÅé
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¡A¤]³\¤£¤Ö¬O·»¤J²{¦bªºº~¤H¤¤¡C±q493A¡÷G¡B1360C¡÷T¤×¨ä¬Ý±o¥X¨Ó
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¡÷T©Î¨ä¥Lªº¬ðÅÜÅé¡A¦]²V¦å³o¨Ç¥®H±Ú°ò¦]·»¤J²{¦bªºº~¤H¡A¦³¨Ç¤]
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¨Ç ÃÒ ¾Ú¡C
¥H¤W°Q½×§¡¬OÓ¤H¦¬¶°¸ê®Æ¬ãŪ«áªº¤ß±o¡A«D¤HÃþ¾Ç®a§ó«D±q
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ª¾¹D¥xÆWÂå¬É¥Íª«¬É¹ïG6PD¬ã¨s¦¨ªG»·»·¶W¹L¨È¬w¨ä¥LG6PD²±¦æ¦a°Ï
¡A¤]¬O³o¦¸§ä¸ê®Æ³Ì°ª¿³ªº¦a¤è¡A«D±`·PÁÂ¥L/¦o̪º§V¤O¤~¦³¤£¤Ö¼Æ
¾Ú¥i¨Ñ°Q½×¡C
¡]¤¡^µ² ½× ¡R
¥xÆWG6PD¤À¤l¥Íª«¾Ç¤wª¾ªº¬ðÅÜÅé³Ì¤Ö¦³¤Q¤ºØ
¡A³Ì¥Dn¦³¤ºØ¡C³Ì¦hªº¬ðÅÜÅé»PµØ«n©ÎªF«n¨Èªº¬Û¦P¡A¦³¨Ç«h»P«n
®q±Ú¸s¦³¬Û¦Pªº¬ðÅÜÅé¡C±q¤ñ¸û¥xÆW¤ÎªþªñªºG6PDªº¬ðÅÜÅé¡A¥xÆWªº
ì¦í¥Á»Pº~¤H¤ÎµØ«nº~¤H»P¤Ö¼Æ¥Á±Ú¦³¥i¯à¦³¦P¤@¯ª¥ý¡C¥xÆW©ÎµØ«n
ªºº~¤H¤£½×«È®a¡BºÖ¦Ñ¥Dn·½¦ÛµØ«n¡A¤£¤Ó¥i¯à¦ÛµØ¥_(¤¤ì)¤jÁ|«n
¾E²¾¥Á ¦Ó¨Ó ¡C
¡] ¤»¡^ English Abstract from Pediat Reserch 45 (4): 101A, 1999
Glucose-6-phosphate Dehydrogenase(G6PD) Mutations and Population
Movement in Taiwan and Neighboring Countries.
Jen-Yih Chu, Division of Hematology/Oncology, Department of
Pediatrics, Saint Louis University School of Medicine, St. Louis,MO
The vast majority of more than 100 molecularly identified G6PD mutants are
single amino acid replacements caused by single missense nucleotide
mutations. We collected the mutant information from the published reports
from Taiwan and surrounding countries. The two most common mutants in
Taiwan, 1376GT and 1388GA, or their biochemically equivalent mutants
were commonly found in southern China, Thailand, Vietnam, Singapore,
Laos, Malaysia, and Indonesia. The third most common 493AG mutant in
Taiwan has not been found in China or overseas Chinese but is a relatively
common mutant in the Philippines. This mutant is the most common one
among one aboriginal group—the Siasiat. Two other uncommon 1360CT
and 487GA mutants in Taiwan have not been found in China. However,
1360CT is the most common mutant in the Philippines and is also found in
the Vanuatu islands in Melanesia. The 487GA mutant is more common in
other Southeast Asian countries. Another uncommon 592CT mutant in
Taiwan is the most common one in another aboriginal group—the Ami and
this mutant can also be found in China and Laos. F8C/G6PD polymorphism
studies are available from certain areas. Han and aboriginal groups in
Taiwan have a similar pattern suggesting they might have the same
ancestors. The same F8C/G6PD haplotype was found in 1376GT mutants in
the Taiwanese and the Li minority in Hainan, China. The G6PD mutant and
F8C/G6PD polymorphism studies suggest that the Han and minorities of
southern China, southeastern Asians, Han and aboriginal groups in Taiwan
probably originate from the same ancestors somewhere in Southeast Asia or
southern China. Partial ancestry of the current Han population in Taiwan
might come from aboriginal groups. Some aboriginal groups of Taiwan might
have originally migrated from the Philippines, or Taiwan is the ancestral
origin for Taiwanese aboriginal groups, Filipinos and other southern Pacific
Islanders as some recent studies suggested. G6PD deficiency is very low
in northern China and the mutants found in southern China and Taiwan have
not been reported in northern China. The myth that the current Han
population in Taiwan and southern China are the descendants of massive
migration of northern Chinese is highly unlikely.
¡] ¤C ¡^ °Ñ ¦Ò ¤å Äm ¡R
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